BAY 11-7085

BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM[1].

Product Specifications

CAS Number

[196309-76-9]

Product Name Alternative

BAY 11-7083

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Ferroptosis; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BAY_11-7085.html

Purity

99.99

Solubility

DMSO : ≥ 26 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#C/C=C/S(C(C=C1)=CC=C1C(C)(C)C)(=O)=O

Molecular Formula

C13H15NO2S

Molecular Weight

249.33

Precautions

H302

References & Citations

[1]Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272 (34) :21096-103.|[2]Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293 (1) :E16-23.