PROTAC MDM2 Degrader-2

PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader. PROTAC MDM2 Degrader-2 can induce the self-ubiquitination and degradation of MDM2, thereby upregulating the level of p53 protein. PROTAC MDM2 Degrader-2 has anti-tumor activity and can be used in the study of cancer[1]. (Blue: MDM2 ligand (HY-128836) ; Black: linker (HY-128833) )

Product Specifications

CAS Number

[2249944-99-6]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; MDM-2/p53; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-mdm2-degrader-2.html

Purity

96.01

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CC(N(CC(NCCOCCOCCNC(CN2C(CN(C(N3[C@@H](C4=CC=C(Cl)C=C4)[C@@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@@H](C8=CC=C(Cl)C=C8)[C@@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

Molecular Formula

C70H76Cl4N10O12

Molecular Weight

1391.22

References & Citations

[1]Chunqi. H, et al. Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A. 2018-10-02.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MDM2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

JH920338 1 Each

Benzenepropanamide, a-methyl-

Ask

View Details

C04635 1 mg

Inolitazone dihydrochloride

Ask

View Details

NBP2-79850FR 0.1 mL

Rabbit Monoclonal Ig gamma-4 Chain C Region Antibody (IGHG4/2042R) [DyLight 680]

Ask

View Details