Suc-[Glu9, Ala11,15]-Endothelin-1 (8-21)

<strong>Suc-[Glu9, Ala11,15]-Endothelin-1 (8-21)</strong> <strong>Catalog number:</strong> MDP0656 <strong>CAS Number: </strong>214050-22-3 <strong>Sequence: </strong>Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp (Suc: Succinyl) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 1820.8 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Mazzoni MR, Breschi MC, Ceccarelli F, Lazzeri N, Giusti L, Nieri P, Lucacchini A. Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus Br J Pharmacol. 1999 Jul;127(6):1406-14. 2: Takai M, Umemura I, Yamasaki K, Watakabe T, Fujitani Y, Oda K, Urade Y, Inui T, Yamamura T, Okada T. A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor Biochem Biophys Res Commun. 1992 Apr 30;184(2):953-9. 3: Watakabe T, Urade Y, Takai M, Umemura I, Okada T. A reversible radioligand specific for the ETB receptor: [125I]Tyr13-Suc-[Glu9,Ala11,15]-endothelin-1(8- 21), [125I]IRL 1620 Biochem Biophys Res Commun. 1992 Jun 30;185(3):867-73. 4: Katahira R, Umemura I, Takai M, Oda K, Okada T, Nosaka AY. Structural studies on endothelin receptor subtype B specific agonist IRL 1620 [suc-[Glu9, Ala11,15]ET-1(8-21)] and its analogs with dipalmitoyl phosphatidylcholine vesicles by NMR spectroscopy J Pept Res. 1998 Feb;51(2):155-64. 5: Fernandez N, Monge L, Garcia-Villalon AL, Garcia JL, Gomez B, Dieguez G. Endothelin-1-induced in vitro cerebral venoconstriction is mediated by endothelin ETA receptors Eur J Pharmacol. 1995 Dec 29;294(2-3):483-90. 6: Semler DE, Ohlstein EH, Nambi P, Slater C, Stern PH. Endothelin-1-evoked calcium transients in UMR-106 osteoblastic osteosarcoma cells are mediated through endothelin-A and endothelin-B receptors J Pharmacol Exp Ther. 1995 Mar;272(3):1052-8. 7: Wang QD, Li XS, Pernow J. Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists Eur J Pharmacol. 1994 Dec 12;271(1):25-30. 8: García JL, Fernández N, García-Villalón AL, Monge L, Gómez B, Diéguez G. Coronary vasoconstriction by endothelin-1 in anesthetized goats: role of endothelin receptors, nitric oxide and prostanoids Eur J Pharmacol. 1996 Nov 14;315(2):179-86. 9: Higuchi H, Satoh T. Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ET(B) receptors in isolated perfused rat liver Eur J Pharmacol. 1997 Jun 11;328(2-3):175-82. <a href="https://pubmed.ncbi.nlm.nih.gov/8271226">10: Pinheiro JM, Malik AB. Mechanisms of endothelin-1-induced pulmonary vasodilatation in neonatal pigs J Physiol. 1993 Sep;469:739-52. </a> <br><strong>Products Related to Suc-[Glu9, Ala11,15]-Endothelin-1 (8-21) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>