5-Hydroxytryptophan
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3].
Product Specifications
CAS Number
56-69-9
Product Name Alternative
5-HTP; DL-5-Hydroxytryptophan
UNSPSC
12352005
Hazard Statement
H301
Target
5-HT Receptor; Endogenous Metabolite
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-hydroxytryptophan.html
Purity
99.92
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)
Smiles
NC(CC1=CNC2=CC=C(O)C=C12)C(O)=O
Molecular Formula
C11H12N2O3
Molecular Weight
220.23
Precautions
H301
References & Citations
[1]Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179 (1-2) :103-9.|[2]Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22 (2) :183-9.|[3]Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113 (3) :237-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Available Sizes
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