5-Hydroxytryptophan

5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3].

Product Specifications

CAS Number

[56-69-9]

Product Name Alternative

5-HTP; DL-5-Hydroxytryptophan

UNSPSC

12352005

Hazard Statement

H301

Target

5-HT Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-hydroxytryptophan.html

Purity

99.92

Solubility

DMSO : 83.33 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)

Smiles

NC(CC1=CNC2=CC=C(O)C=C12)C(O)=O

Molecular Formula

C11H12N2O3

Molecular Weight

220.23

Precautions

H301

References & Citations

[1]Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179 (1-2) :103-9.|[2]Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22 (2) :183-9.|[3]Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113 (3) :237-43.