Succinobucol
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects.
Product Specifications
CAS Number
216167-82-7
Product Name Alternative
AGI-1067; Probucol monosuccinate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Succinobucol.html
Purity
99.62
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OC(CCC(O)=O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O
Molecular Formula
C35H52O5S2
Molecular Weight
616.91
Precautions
H302, H315, H319, H335
References & Citations
[1]Houston SA, et al. An investigation of the antiplatelet effects of succinobucol (AGI-1067) . Platelets. 2017 May;28 (3) :295-300.|[2]Colle D, et al. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity. Mol Neurobiol. 2016 Mar;53 (2) :1280-95.|[3]Dan Z, et al. A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer. Theranostics. 2016 Jan 25;6 (3) :435-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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