Succinobucol

Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects.

Product Specifications

CAS Number

[216167-82-7]

Product Name Alternative

AGI-1067; Probucol monosuccinate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Succinobucol.html

Purity

99.62

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OC(CCC(O)=O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O

Molecular Formula

C35H52O5S2

Molecular Weight

616.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Houston SA, et al. An investigation of the antiplatelet effects of succinobucol (AGI-1067) . Platelets. 2017 May;28 (3) :295-300.|[2]Colle D, et al. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity. Mol Neurobiol. 2016 Mar;53 (2) :1280-95.|[3]Dan Z, et al. A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer. Theranostics. 2016 Jan 25;6 (3) :435-45.