SGK1-IN-5
SGK1-IN-5 (Compound 1) is an inhibitor for serum and glucocorticoid regulated kinase SGK 1 with an IC50 of 3 nM. SGK1-IN-5 inhibits SGK-1 dependent phosphorylation of GSK3β in U2OS cells with an IC50 of 1.4 μM. SGK1-IN-5 can be used in research about osteoarthritis or rheumatism[1].
Product Specifications
CAS Number
[1426214-51-8]
UNSPSC
12352005
Target
SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sgk1-in-5.html
Smiles
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O
Molecular Formula
C17H12Cl2N6O2S
Molecular Weight
435.29
References & Citations
[1]Nazare M, et al., N-[4- (1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL) -PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS. US20130072493.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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AP4M1, ID (AP4M1, MUARP2, AP-4 complex subunit mu-1, AP-4 adapter complex mu subunit, Adapter-related protein complex 4 mu-1 subunit, Mu subunit of AP-4, Mu-adaptin-related protein 2, Mu4-adaptin) (MaxLight 650)
