Recombinant Human PLK1 Protein (Full Length, His Tag, Active)

<strong>Recombinant Human PLK1 Protein (Full Length, His Tag, Active)</strong>_x000D_ <strong>Catalog number:</strong> B2018976_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~70 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> PLK Protein, Human; STPK13 Protein, Human_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt JC, Sfeir A. RHINO directs MMEJ to repair DNA breaks in mitosis Science. 2023 Aug 11;381(6658):653-660._x000D_ 2: Gelot C, Kovacs MT, Miron S, Mylne E, Haan A, Boeffard-Dosierre L, Ghouil R, Popova T, Dingli F, Loew D, Guirouilh-Barbat J, Del Nery E, Zinn-Justin S, Ceccaldi R. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis Nature. 2023 Sep;621(7978):415-422._x000D_ 3: Piché J, Van Vliet PP, Pucéat M, Andelfinger G. The expanding phenotypes of cohesinopathies: one ring to rule them all! Cell Cycle. 2019 Nov;18(21):2828-2848._x000D_ 4: Nagelli S, Westermarck J. CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response Trends Cancer. 2024 Jan;10(1):52-64._x000D_ 5: Peng Y, Liu Y, Gao Y, Yuan B, Qi X, Fu Y, Zhu Q, Cao T, Zhang S, Yin L, Li X. USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis J Exp Clin Cancer Res. 2019 Nov 15;38(1):468._x000D_ 6: Metzger T, Kleiss C, Sumara I. CUL3 and protein kinases: insights from PLK1/KLHL22 interaction Cell Cycle. 2013 Jul 15;12(14):2291-6._x000D_ 7: Guervilly JH, Gaillard PH. SLX4: multitasking to maintain genome stability Crit Rev Biochem Mol Biol. 2018 Oct;53(5):475-514._x000D_ 8: Golsteyn RM, Mundt KE, Fry AM, Nigg EA. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function J Cell Biol. 1995 Jun;129(6):1617-28._x000D_ 9: Cheng L, Ke Y, Yu S, Jing J. Co-delivery of doxorubicin and recombinant plasmid pHSP70-Plk1-shRNA by bacterial magnetosomes for osteosarcoma therapy Int J Nanomedicine. 2016 Oct 25;11:5277-5286._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/38959179">10: Li W, Hao Y. Polo-Like Kinase 1 and DNA Damage Response DNA Cell Biol. 2024 Sep;43(9):430-437. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human PLK1 Protein (Full Length, His Tag, Active) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>