Gnetol

Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities[1][2][3].

Product Specifications

CAS Number

[86361-55-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX; HDAC; Tyrosinase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gnetol.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=CC(O)=C1/C=C/C2=CC(O)=CC(O)=C2

Molecular Formula

C14H12O4

Molecular Weight

244.24

Precautions

H315, H319, H335

References & Citations

[1]Remsberg CM, et al. Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs. Phytother Res. 2015 Aug;29 (8) :1168-79.|[2]Ohguchi K, et al. Gnetol as a potent tyrosinase inhibitor from genus Gnetum. Biosci Biotechnol Biochem. 2003 Mar;67 (3) :663-5.|[3]Jinadatta P, et al. In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Gnetum ula Brongn. Bioimpacts. 2019;9 (4) :239-249.