Gnetol
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities[1][2][3].
Product Specifications
CAS Number
[86361-55-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
COX; HDAC; Tyrosinase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gnetol.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(O)=C1/C=C/C2=CC(O)=CC(O)=C2
Molecular Formula
C14H12O4
Molecular Weight
244.24
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126052/Gnetol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126052/Gnetol-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1
Available Sizes
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