Coibamide A

Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts[1][2].

Product Specifications

CAS Number

[1029227-48-2]

UNSPSC

12352209

Target

Apoptosis; Autophagy; VEGFR

Type

Peptides

Related Pathways

Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/coibamide-a.html

Solubility

10 mM in DMSO

Smiles

CC(C)[C@H](N(C)C)C(O[C@H](C(C)C)C(N(C)[C@@H](COC)C(N(C)[C@@H](CC(C)C)C(N([C@@H]1C(N([C@H](C(N([C@@](C(N[C@H](C(N([C@H](C(N[C@H](C(N([C@@H](C(O[C@@H]1C)=O)C)C)=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)C)=O)C)=O)([H])[C@@H](C)CC)C)=O)COC)C)=O)C)=O)=O)=O)=O

Molecular Formula

C65H110N10O16

Molecular Weight

1287.63

References & Citations

[1]Andrew M Hau, et al. Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One. 2013 Jun 6;8 (6) :e65250.|[2]Jeffrey D Serrill, et al. Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts. Invest New Drugs. 2016 Feb;34 (1) :24-40.