Coibamide A
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts[1][2].
Product Specifications
CAS Number
1029227-48-2
UNSPSC
12352209
Target
Apoptosis; Autophagy; VEGFR
Type
Peptides
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/coibamide-a.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@H](N(C)C)C(O[C@H](C(C)C)C(N(C)[C@@H](COC)C(N(C)[C@@H](CC(C)C)C(N([C@@H]1C(N([C@H](C(N([C@@](C(N[C@H](C(N([C@H](C(N[C@H](C(N([C@@H](C(O[C@@H]1C)=O)C)C)=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)C)=O)C)=O)([H])[C@@H](C)CC)C)=O)COC)C)=O)C)=O)=O)=O)=O
Molecular Formula
C65H110N10O16
Molecular Weight
1287.63
References & Citations
[1]Andrew M Hau, et al. Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One. 2013 Jun 6;8 (6) :e65250.|[2]Jeffrey D Serrill, et al. Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts. Invest New Drugs. 2016 Feb;34 (1) :24-40.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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