Eicosanoyl-5-hydroxytryptamide

A neuroprotective natural product found in coffee

Product Specifications

Background

A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).

Product Name Alternative

Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Synuclein

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.005

Format

Beige powder

Solubility

May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)

Molecular Formula

C30H50N2O2

Molecular Weight

470.7

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E12053 2. Asam K., et al. (2017) PLoS One. 12:e0189413 3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701