Nolomirole (hydrochloride)

Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750) -induced congestive heart failure model. Nolomirole increases cardiac output[1][2].

Product Specifications

CAS Number

[138531-51-8]

Product Name Alternative

CHF 1035

UNSPSC

12352005

Target

Adrenergic Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nolomirole-hydrochloride.html

Smiles

CC(C)C(OC1=C2C(CC(NC)CC2)=CC=C1OC(C(C)C)=O)=O.Cl

Molecular Formula

C19H28ClNO4

Molecular Weight

369.88

References & Citations

[1]Pasini E, et al. Effect of nolomirole on monocrotaline-induced heart failure. Pharmacol Res. 2004 Jan;49 (1) :1-5. |[2]Torp-Pedersen C, et al. A randomised trial of a pre-synaptic stimulator of DA2-dopaminergic and alpha2-adrenergic receptors on morbidity and mortality in patients with heart failure. Eur J Heart Fail. 2008 Jan;10 (1) :89-95.