Neopterin

Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring[1][2][3][4][5].

Product Specifications

CAS Number

[2009-64-5]

Product Name Alternative

D- (+) -Neopterin; D-erythro-Neopterin

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

ERK; NF-κB; PPAR; Raf; Src

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/D-__addition__-Neopterin.html

Purity

99.90

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(N=CC([C@H](O)[C@H](O)CO)=N2)=NC(N)=N1

Molecular Formula

C9H11N5O4

Molecular Weight

253.21

Precautions

H315, H319, H335

References & Citations

[1]Shirai R, et al. Neopterin Counters Vascular Inflammation and Atherosclerosis. J Am Heart Assoc. 2018 Feb 2;7 (3) :e007359.|[2]Aisaki K, et al. Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment. Exp Biol Med (Maywood) . 2012 Mar;237 (3) :279-86.|[3]Fuchs D, et al. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci. 1992;29 (3-4) :307-41.|[4]Sucher R, et al. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010 Jan 1;287 (1) :13-22.|[5]Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3 (2) :175-187].