PKUMDL-WQ-2101
Product Specifications
UNSPSC Description
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1].
Target Antigen
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkumdl-wq-2101.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O
Molecular Weight
317.25
References & Citations
[1]Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24(1):55-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123269/PKUMDL-WQ-2101-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123269/PKUMDL-WQ-2101-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
304481-72-9
Available Sizes
Curated Selection
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