PKUMDL-WQ-2101
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1].
Product Specifications
CAS Number
[304481-72-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkumdl-wq-2101.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O
Molecular Formula
C14H11N3O6
Molecular Weight
317.25
Precautions
H315, H319, H335
References & Citations
[1]Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24 (1) :55-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
A0923-55E 200 µL
AF9, NT (H54) (Protein AF-9, ALL1-fused Gene From Chromosome 9 Protein, Myeloid/Lymphoid Or Mixed-lineage Leukemia Translocated To Chromosome 3 Protein, YEATS Domain-containing Protein, MLLT3, YEATS3)
Sign In for Pricing
View Details 
K1591107 1.0 µg DNA
PAMR1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
126462-ML405 100 µL
ESM1 (Endothelial Cell-specific Molecule 1, ESM-1) (MaxLight 405) discontinued
Sign In for Pricing
View Details