PKUMDL-WQ-2101
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1].
Product Specifications
CAS Number
[304481-72-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkumdl-wq-2101.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O
Molecular Formula
C14H11N3O6
Molecular Weight
317.25
Precautions
H315, H319, H335
References & Citations
[1]Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24 (1) :55-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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