PKUMDL-WQ-2101

PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1].

Product Specifications

CAS Number

[304481-72-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphoglycerate Dehydrogenase (PHGDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pkumdl-wq-2101.html

Purity

99.94

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1O)O)N/N=C/C2=CC([N+]([O-])=O)=CC=C2O

Molecular Formula

C14H11N3O6

Molecular Weight

317.25

Precautions

H315, H319, H335

References & Citations

[1]Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24 (1) :55-65.