GNE-431
GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM) . GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases[1][2].
Product Specifications
CAS Number
1433820-83-7
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gne-431.html
Smiles
O=C1N(C2=NC=CC(C3=NN4C(C(NC5=NN6C(CN(C)CC6)=C5)=C3)=NC=C4)=C2CO)CCN7C1=CC8=C7CCCC8
Molecular Formula
C30H32N10O2
Molecular Weight
564.64
References & Citations
[1]Tasso B, et al. The Development of BTK Inhibitors: A Five-Year Update. Molecules. 2021 Dec 6;26 (23) :7411.|[2]Brullo C, et al. Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective. Int J Mol Sci. 2021 Jul 16;22 (14) :7641.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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