GNE-431

GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM) . GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases[1][2].

Product Specifications

CAS Number

[1433820-83-7]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gne-431.html

Smiles

O=C1N(C2=NC=CC(C3=NN4C(C(NC5=NN6C(CN(C)CC6)=C5)=C3)=NC=C4)=C2CO)CCN7C1=CC8=C7CCCC8

Molecular Formula

C30H32N10O2

Molecular Weight

564.64

References & Citations

[1]Tasso B, et al. The Development of BTK Inhibitors: A Five-Year Update. Molecules. 2021 Dec 6;26 (23) :7411.|[2]Brullo C, et al. Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective. Int J Mol Sci. 2021 Jul 16;22 (14) :7641.