β-Catenin modulator-7
β-Catenin modulator-7 (Compound 5) is a modulator for β-catenin. β-Catenin modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC50 of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer[1].
Product Specifications
CAS Number
2892294-93-6
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-modulator-7.html
Smiles
[O-]/[N+](N(CC)CC)=N\OCOC(CCCCOC1=C(OC)C=C(/C=C/C(N(CCC=C2Cl)C2=O)=O)C=C1OC)=O
Molecular Formula
C26H35ClN4O9
Molecular Weight
583.03
References & Citations
[1]Zou Y, et al., Discovery of Cytotoxic Nitric Oxide-Releasing Piperlongumine Derivatives Targeting Wnt/β-Catenin in Colon Cancer Cells. J Nat Prod. 2024 Jul 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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