β-Catenin modulator-7
β-Catenin modulator-7 (Compound 5) is a modulator for β-catenin. β-Catenin modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC50 of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer[1].
Product Specifications
CAS Number
2892294-93-6
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-modulator-7.html
Smiles
[O-]/[N+](N(CC)CC)=N\OCOC(CCCCOC1=C(OC)C=C(/C=C/C(N(CCC=C2Cl)C2=O)=O)C=C1OC)=O
Molecular Formula
C26H35ClN4O9
Molecular Weight
583.03
References & Citations
[1]Zou Y, et al., Discovery of Cytotoxic Nitric Oxide-Releasing Piperlongumine Derivatives Targeting Wnt/β-Catenin in Colon Cancer Cells. J Nat Prod. 2024 Jul 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
