DL-175

DL-175 (compound 13) is a selective GPR84 agonist with biased agonistic activity. DL-175 can selectively activate functional responses in immune cells and induce enhanced chemotaxis and phagocytosis of human bone marrow cells. DL-175 is a potential chemical probe[1].

Product Specifications

CAS Number

[2487253-25-6]

UNSPSC

12352005

Target

GPR84

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dl-175.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

ClC1=C2C=CC=CC2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

Molecular Formula

C17H14ClNO2

Molecular Weight

299.75

References & Citations

[1]Lucy D, et al. A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages. ACS Chem Biol. 2019 Sep 20;14 (9) :2055-2064.