Amgen-23
Product Specifications
UNSPSC Description
Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1].
Target Antigen
SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amgen-23.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1C2=CSC(NC3=CC=C(C=C3)CCN4[C@H](C[C@H](CC4)O)CO)=N2)=C(C=C1)Cl
Molecular Weight
478.43
References & Citations
[1]Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147282/Amgen-23-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147282/Amgen-23-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1448706-15-7
Available Sizes
Curated Selection
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