Amgen-23

Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1].

Product Specifications

CAS Number

[1448706-15-7]

UNSPSC

12352005

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amgen-23.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C=C1C2=CSC(NC3=CC=C(C=C3)CCN4[C@H](C[C@H](CC4)O)CO)=N2)=C(C=C1)Cl

Molecular Formula

C23H25Cl2N3O2S

Molecular Weight

478.43

References & Citations

[1]Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4608-16.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SphK1; SphK2

Available Sizes

Curated Selection

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