THZ1-R
THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.
Product Specifications
CAS Number
[1621523-07-6]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/THZ1-R.html
Purity
98.06
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(CCCN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54
Molecular Formula
C31H30ClN7O2
Molecular Weight
568.07
References & Citations
[1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511 (7511) :616-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK7
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2065430-01 0.1 mL
PE-Linked Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1)
Ask
View Details MBS2065430-02 0.2 mL
PE-Linked Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1)
Ask
View Details MBS2065430-03 0.5 mL
PE-Linked Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1)
Ask
View Details 
MBS2065430-04 1 mL
PE-Linked Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1)
Ask
View Details MBS2065430-05 5 mL
PE-Linked Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1)
Ask
View Details