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IL-2R gamma/CD132, Rat (HEK293, hFc)

IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma takes part in inflammatory response and mediates activation of the cells [1][2]. IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types[3]. IL-2R gamma/CD132 Protein, Rat (HEK293, hFc) is a recombinant rat extracellular region of IL-2R beta (S25-A262) with a C-Terminal hFc tag, which is produced in HEK293 cells.

Product Specifications

Product Name Alternative

IL-2R gamma/CD132 Protein, Rat (HEK293, hFc), Rat, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-2r-gamma-cd132-protein-rat-hek293-hfc.html

Molecular Formula

140924 (Gene_ID) Q68FU6 (S25-A262) (Accession)

Molecular Weight

Approximately 67 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]X Cao, et al. Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression. Proc Natl Acad Sci U S A. 1993 Sep 15;90 (18) :8464-10.|[2]S Hodge, et al. Surface and intracellular interleukin-2 receptor expression on various resting and activated populations involved in cell-mediated immunity in human peripheral blood. Scand J Immunol. 2000 Jan;51 (1) :67-74.|[3]W P Weidanz, et al. Signalling through the IL-2 receptor γ (c) peptide (CD134) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria.|[4]Xinglong Yang, et al. An Immune System-Modified Rat Model for Human Stem Cell Transplantation Research. Stem Cell Reports. 2018 Aug 14;11 (2) :514-521.|[5]Mengmeng Zhao, et al. Expression of Interleukin-2 receptor subunit gamma (IL-2Rγ) and its binding with IL-2 induced activation of CD4 T lymphocytes in flounder (Paralichthys olivaceus) . Fish Shellfish Immunol. 2022 Mar;122:426-436.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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