WAY208466 (dihydrochloride)

WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor) . WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex[1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects[2].

Product Specifications

CAS Number

[1207064-61-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/way208466-dihydrochloride.html

Purity

98.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCN1C=C(S(=O)(C2=CC=CC(F)=C2)=O)C3=CC=CN=C31.[H]Cl.[H]Cl

Molecular Formula

C17H20Cl2FN3O2S

Molecular Weight

420.33

Precautions

H315, H319, H335

References & Citations

[1]Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33 (6) :1323-35. |[2]Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl) . 2011 Feb;213 (2-3) :499-507.