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GM-60186

GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gm-60186.html

Concentration

10mM

Purity

99.34

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=CC(CCC2=CC=CC=C2OCC(O)CN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=C1

Molecular Formula

C30H33FN2O4

Molecular Weight

504.59

References & Citations

[1]Jeong-Yun Lee, et al. Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling. Biomed Pharmacother. 2024 Oct:179:117428.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α-1 microglobulin

Available Sizes

Frequently Asked Questions

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