GM-60186
GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gm-60186.html
Concentration
10mM
Purity
99.34
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC(CCC2=CC=CC=C2OCC(O)CN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=C1
Molecular Formula
C30H33FN2O4
Molecular Weight
504.59
References & Citations
[1]Jeong-Yun Lee, et al. Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling. Biomed Pharmacother. 2024 Oct:179:117428.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-1 microglobulin
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681866-100 1x 100 µL
Calponin-1 (Smooth Muscle Marker) (rCNN1/832), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC682608-500 1x 500 µL
NRF1 (NRF1/2608), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TP325235M 100 µg
Vgl4 (VGLL4) (NM_001128221) Human Recombinant Protein
Sign In for Pricing
View Details