Ebelactone A
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively[1]. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis[2].
Product Specifications
CAS Number
76808-16-7
UNSPSC
12352005
Target
Lipase; MetAP
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/ebelactone-a.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@@H]([C@@]1([H])[C@@H](C(O1)=O)C)C)=O
Molecular Formula
C20H34O4
Molecular Weight
338.48
References & Citations
[1]Umezawa H, et al., Ebelactone, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo) . 1980 Dec;33 (12) :1594-6.|[2]Francis S A, et al., The role of cutinase in germling development and infection byErysiphe graminisf. sp. hordei[J]. Physiological and Molecular Plant Pathology, 1996, 49 (3) : 201-211.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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