Pipecolic acid

Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].

Product Specifications

CAS Number

[535-75-1]

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; YAP

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Pipecolic_acid.html

Purity

99.92

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1CCCCN1

Molecular Formula

C6H11NO2

Molecular Weight

129.16

Precautions

H315, H319, H335

References & Citations

[1]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33 (6) :401-7.|[2]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36 (3) :200-5.|[3]Liying Luo, et al. "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling." Biomedicine & Pharmacotherapy 169 (2023) : 115895.