Pipecolic acid
Product Specifications
UNSPSC Description
Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].
Target Antigen
Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; YAP
Type
Biochemical Assay Reagents
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pipecolic_acid.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C1CCCCN1
Molecular Weight
129.16
References & Citations
[1]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7.|[2]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5.|[3]Liying Luo, et al. "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling." Biomedicine & Pharmacotherapy 169 (2023): 115895.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-Y0669/Pipecolic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-Y0669/Pipecolic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
535-75-1
Available Sizes
Curated Selection
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