BMS-566394
BMS-566394 is a potent inhibitor of tumor necrosis factor-α (TNF-α) converting enzyme (TACE) that helps reduce the production of TNF-α, thereby alleviating inflammation and immune-mediated diseases and can be used in the study of inflammatory and autoimmune diseases[1].
Product Specifications
CAS Number
503166-51-6
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/bms-566394.html
Smiles
O=C(N[C@H](CCOC1)[C@H]1C(NO)=O)C(C=C2)=CC=C2CN3C(C(F)(F)F)=NC4=CC=CC=C34
Molecular Formula
C22H21F3N4O4
Molecular Weight
462.42
References & Citations
[1]Sengupta P, et al. Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE[J]. European journal of medicinal chemistry, 2011, 46 (11) : 5549-5555.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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