CUR61414
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM) . CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].
Product Specifications
CAS Number
[334998-36-6]
Product Name Alternative
CC 122,CC 122 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cur61414.html
Concentration
10mM
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Molecular Formula
C31H42N4O5
Molecular Weight
550.69
Precautions
H301
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113965/CUR61414-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113965/CUR61414-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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