Thalidomide-NH-CBP/p300 ligand 2
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440) [1].
Product Specifications
CAS Number
[2484739-21-9]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Molecular Glues; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-cbp-p300-ligand-2.html
Purity
98.55
Solubility
DMSO : 113.33 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCCCCCCNC4=CC=C5C(N(C6C(NC(CC6)=O)=O)C(C5=C4)=O)=O)=O)N=C2N7C8=C(CCC7)C=C(C9=CN(C)N=C9)C(C(F)F)=C8)NC
Molecular Formula
C48H57F2N11O6
Molecular Weight
922.03
References & Citations
[1]LIU JING, et al. CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE. Patent WO2020173440.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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