TETi76
TETi76 is an orally active TET family inhibitor with IC50 values of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].
Product Specifications
CAS Number
[1451750-73-4]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
TET Protein
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/teti76.html
Purity
97.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC)C(O)CC(C(OCC)=O)=C
Molecular Formula
C10H16O5
Molecular Weight
216.23
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TET1; TET2; TET3
Available Sizes
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