EGIS-7625

EGIS-7625 is a selective and competitive 5-HT2B inhibitor with pKi values of 9.0, 6.2, 7.7 for 5-HT2B, 5-HT2A, 5-HT2C, respective. EGIS-7625 partially attenuates m-chlorophenylpiperazine-induced hypomotility and hypophagia[1].

Product Specifications

CAS Number

[755040-97-2]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/egis-7625.html

Smiles

NC1=CC(N2CCN(CC3=CC=CC=C3)CC2)=C([N+]([O-])=O)C=C1C.Cl.Cl

Molecular Formula

C18H24Cl2N4O2

Molecular Weight

399.31

References & Citations

[1]Kovács A, et al. Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17 (5-6) :427-34.