Lucanthone
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .
Product Specifications
CAS Number
[479-50-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Lucanthone.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC
Molecular Formula
C20H24N2OS
Molecular Weight
340.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11 (1) :109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286 (8) :6602-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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