Lucanthone

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .

Product Specifications

CAS Number

[479-50-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Lucanthone.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC

Molecular Formula

C20H24N2OS

Molecular Weight

340.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11 (1) :109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286 (8) :6602-13.