PROTAC GPX4 degrader-1
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
Product Specifications
CAS Number
[2916433-81-1]
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-gpx4-degrader-1.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C(C2=CC=C(C=C2)OCC(N3CCC(CC3)CN4CCN(CCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)CC4)=O)C8=CC=C(C=C8)Cl)CC1)C9=NOC(C)=C9[N+]([O-])=O
Molecular Formula
C50H57ClN10O10
Molecular Weight
993.50
References & Citations
[1]Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15359112 1 Vial
Lentiviral human UBD sgRNA gene knockout kit - Lentiviral human UBD sgRNA gene knockout kit (25)
Ask
View Details