PROTAC GPX4 degrader-1
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
Product Specifications
CAS Number
[2916433-81-1]
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-gpx4-degrader-1.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C(C2=CC=C(C=C2)OCC(N3CCC(CC3)CN4CCN(CCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)CC4)=O)C8=CC=C(C=C8)Cl)CC1)C9=NOC(C)=C9[N+]([O-])=O
Molecular Formula
C50H57ClN10O10
Molecular Weight
993.50
References & Citations
[1]Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal OCT4 Antibody [mFluor Violet 610 SE]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
MBS6212642-01 0.1 mL
Mucin 1 (MUC1, Mucin-1, MUC-1, Breast Carcinoma-associated Antigen DF3, Carcinoma-associated Mucin, Episialin, H23AG, PEMT, Peanut-reactive Urinary Mucin, PUM, Polymorphic Epithelial Mucin, PEM, Tumor-associated Epithelial Membrane Antigen, EMA, Tumor-ass
Ask
View Details MBS6212642-02 5x 0.1 mL
Mucin 1 (MUC1, Mucin-1, MUC-1, Breast Carcinoma-associated Antigen DF3, Carcinoma-associated Mucin, Episialin, H23AG, PEMT, Peanut-reactive Urinary Mucin, PUM, Polymorphic Epithelial Mucin, PEM, Tumor-associated Epithelial Membrane Antigen, EMA, Tumor-ass
Ask
View Details 