Brexpiprazole-d8
Brexpiprazole-d8 (OPC-34712-d8) is the deuterium labeled Brexpiprazole. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[3].
Product Specifications
CAS Number
1427049-21-5
Product Name Alternative
OPC-34712-d8
UNSPSC
12352005
Hazard Statement
H302, H400, H410
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.90
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC(OCCCCN3C([2H])([2H])C([2H])([2H])N(C4=C(C=CS5)C5=CC=C4)C([2H])([2H])C3([2H])[2H])=C2)C=C1
Molecular Formula
C25H19D8N3O2S
Molecular Weight
441.62
Precautions
H302, H400, H410
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor
Available Sizes
Frequently Asked Questions
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