What is the catalog number for DAPT?

The catalog number for DAPT is HY-13027.

What sizes are available for DAPT?

DAPT is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg, 200 mg.

How many pack sizes does DAPT come in?

DAPT is available in 6 different pack sizes.

DAPT is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DAPT?

DAPT is manufactured by QuantiMol.

What is the estimated delivery time for DAPT?

Estimated delivery time for DAPT is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DAPT?

The safety data sheet for DAPT is available here: http://file.medchemexpress.com/batch_PDF/HY-13027/DAPT-SDS-MedChemExpress.pdf.

DAPT

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2].

Product Specifications

CAS Number

208255-80-5

Product Name Alternative

GSI-IX

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Apoptosis; Autophagy; Notch; Organoid; γ-secretase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DAPT.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1

Molecular Formula

C23H26F2N2O4

Molecular Weight

432.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Dovey HF, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76 (1) :173-81.|[2]Zhou JX, et al. γ-secretase inhibition combined with NSC 119875 enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3 (2) :357-361.|[3]Li S, et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33 (6) :1257-64.|[4]Tanimizu N, et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016 Jul;64 (1) :175-88.|[5]Michael T. Chang, et al. Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma. Yale University. January 2016.|[6]Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128 (1) :483-499.|[7]Yixin Tao, et al. β-catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis. J Mol Cell Biol. 2018 May 16.