TAK-418
Product Specifications
UNSPSC Description
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models[1][2].
Target Antigen
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tak-418.html
Smiles
O=C(C1=CSC([C@H]2[C@H](NCC3CC3)C2)=C1)NC4CCOCC4.[H]Cl
Molecular Weight
356.91
References & Citations
[1]Baba R, et al. LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. Sci Adv. 2021;7(11):eaba1187. Published 2021 Mar 12.|[2]Zhang L, et al. Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome. Mol Ther Methods Clin Dev. 2021;20:779-791. Published 2021 Feb 18
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138830/TAK-418-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138830/TAK-418-SDS-MedChemExpress.pdf
CAS Number
1818252-53-7
Available Sizes
Curated Selection
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