SHMT-IN-3
SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53 µM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine[1].
Product Specifications
CAS Number
330638-43-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shmt-in-3.html
Purity
98.0
Smiles
OC(CCC(NC1=CC=C(C2=NC(C3=CC=C(NC(CCC(O)=O)=O)C=C3)=NC=C2)C=C1)=O)=O
Molecular Formula
C24H22N4O6
Molecular Weight
462.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Hiroshi Nonaka, et al. Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. Nat Commun. 2019 Feb 20;10 (1) :876.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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