NH125
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also can induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K[1][2].
Product Specifications
CAS Number
278603-08-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Bacterial; CaMK; Fungal; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NH125.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=[N+](CC2=CC=CC=C2)C=CN1CCCCCCCCCCCCCCCC.[I-]
Molecular Formula
C27H45IN2
Molecular Weight
524.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63 (20) :6894-9.|[2]Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2) : a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286 (51) :43951-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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