NH125

NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also can induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K[1][2].

Product Specifications

CAS Number

[278603-08-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bacterial; CaMK; Fungal; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NH125.html

Purity

99.63

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=[N+](CC2=CC=CC=C2)C=CN1CCCCCCCCCCCCCCCC.[I-]

Molecular Formula

C27H45IN2

Molecular Weight

524.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63 (20) :6894-9.|[2]Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2) : a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286 (51) :43951-8.