TPO (Thyroid Peroxidase) (Thyroid Marker)
Product Specifications
Gene Name
[TPO]
NCBI Gene ID
7173
Reactivity
Human
Storage Conditions
Antibody without azide: store at -20 to -80°C.<br>Non-hazardous. No MSDS required.
Specificity
Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Other Gene Names
[TPO; TPO; MSA; TPX; TDH2A; TPO]
Short Name
[TPO (Thyroid Peroxidase)]
Other Product Names
[thyroid peroxidase isoform a; Thyroid peroxidase; thyroid peroxidase; thyroid peroxidase]
NCBI GI Number
28558982
NCBI Accession Number
NP_000538.3
NCBI GB Accession Number
NP_000538.3
Uniprot Accession Number
P07202
Available Sizes
Curated Selection
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